This chapter begins with a brief introduction to microfluidics, followed by a description of the. Dna sequence analysis with dropletbased microfluidics. Microfluidics has recently emerged as a new technology for studies at the small scale ranging from the biological sciences, soft matter, reactions and synthesis, highthroughput drug screening, encapsulation, and labonchip diagnostics whitesides, 2006. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing. Lin basic technologies for droplet microfluidics l. Related content dripping and jetting in microfluidic multiphase flows applied to particle and fibre synthesis j k nunes, s s h tsai, j wan et al. Abstract microfluidic devices for manipulating fluids. Translating nanotechnology and microfluidics for analysis. Microfluidics in engineering journals microfluidics in multidisciplinary journals microfluidics in biology and medicine journals 80% 6% 14% infectious disease 1,200 85% 6% 9% figure 1 microfluidic publications in engineering, multidisciplinary, and biology and.
The research activity is mostly experimental, at the intersection between fluid dynamics, biology and microtechnology. Key words lowreynoldsnumber hydrodynamics, electroosmosis, nanofluidics, microdevices, mixing. Introduction to microfluidics patrick tabeling pdf. In the later teen years and young adulthood, drinking and driving increases greatly. Introduction to microfluidics iii mit opencourseware. Futterer 23092006 why traditional instruments are unsufficient complexity. Wereley provides electrical and mechanical engineers with complete and current coverage of microfluidics an emerging field involving fluid flow and devices in micro scale and nano scale. Presentation on microfluidics and its applications by rajan arora 2. As the name suggests, microfluidics involves fluid flows at. Advances in microfluidics and labonachip technologies. Fundamentals and applications of microfluidics ch1. Dropletbased microfluidics is an upcoming field of research. Kawai flow control methods and devices in micrometer scale channels l. Flow control in paperbased microfluidic devices, s.
Microfluidics mainly deals with artificial systems, but is present in numerous natural systems. We hope it will provide a background knowledge to consult more specialized books or article. The present and future role of microfluidics in biomedical research. This chapter provides an introduction to concepts of microfluidics and microfluidic design. Physical aspects and design consequences of working with fluid flow at the microscale are described. The book wil provide the reader with the concepts, methods and data they need to grasp situations which typically arise in microfluidic systems. Fundamentals and applications of microfluidics book written by the authors namtrung nguyen steven t. Microfluidic and labonachip devices 36 microfluidic devices closed chips continuous flow dropletbased digital microfluidics open chips microfluidic probes mfp microarrays external pressure capillary effect electrokinetic mechanisms electrowettingondielectirc surface acoustic waves optoelectrowetting inkjet printing pinprinting.
Fundamentals and applications of microfluidicsnamtrung nguyen, steve wereley. First, terms are defined and basic fluid dynamic relationships are introduced. Spatiotemporal dynamics of cellularmolecular processes. Urbanski david craig mit hatsopoulos microfluids laboratory prof. Moving, mixing, using microscopic amounts of fluid is. Reactions can be performed in waterinoil droplets biphasic in microchannels, whereby each droplet functions as an independent reactor pico to nanoliter size, as can be seen in figure 5. Controlling the flow and understanding the behavior of fluids at the small scale allows for the miniaturization of fluidic systems, with application ranging from cell manipulation to better diagnostic testing to creation of multiphase flows and structures. Introduction to microfluidics, 2010, 312 pages, patrick. Henrik bruus mic department of micro and nanotechnology technical university of denmark 30 august 2004 this second edition of the lecture notes has bene. Wen electrorheological fluid and its applications in microfluidics j. Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length scales micrometers to millimeters, has become useful for manipulating cells. In the past decade, microfluidic tools to control and manipulate flows at sub millimeter scale, have increasingly been used in a labonchip.
Fundamentals and applications of microfluidics, namtrung nguyen, steven t. Publications and patents microfluidics and biological. Microfluidicsbased automated electrophoresis blanca chang, eric larson, and christina whitmanguliaev, biorad laboratories, inc. Quake departments of applied physics and physics, california institute of technology, pasadena, california 91125, usa. Microfluidics technology has contributed to powerful tools that have helped advance many.
Dropletbased microfluidics offers several unique advantages when compared to conventional. Microfluidicsintroduction wikibooks, open books for an. The reason why we consider it a new discipline is not only the fact that only recently systems have emerged allowing to carry out complex microfluidic protocols, but also due to the different physical regime these systems are based on compared to. The microfluidics module the microfluidics module is used by engineers and scientists to understand, predict, and design microfluidic systems. Artech house integrated microsystems series includes bibliographical references and index. Microfluidics wikibooks, open books for an open world. The book will provide the reader with the concepts, methods and data they. Microfluidics is the science that studies about the process or manipulation of fluids in a channel with the range of small volumes from microliters 10 6 to picoliters 10 12 and the. It has applications in chemical engineering, pharmaceutics, biotechnology and medicine.
Microfluidics is a young and rapidly expanding scientific discipline, which deals with fluids and solutions in miniaturized systems, the socalled labonachip systems. O23 service compaq advisor compaq rba unknown owner c program files compaq compaq advisor bin compaqrba. For example, you might input a fluid such as saliva or blood to be analyzed. Microfluidics can be incorporated into a labonachip which is used as an assay or diagnostic test and replaces its large, costly fullsize lab counterpart. Figure 1 summarizes the various process steps that can be performed by microfluidic methods, and some of their applications to drug discovery. As one of the subcategories of biomimetic materials, artificial cells. Basics and applications kate turner handson workshop in micro and nanobiotechnology. Theoretical microfluidics oxford master series in physics.
Introduction to microfluidics by lnf microfluidics. Introduction to microfluidics iii hydrodynamics and electrokinetics. The lab is located in the department of aerospace and mechanical engineering at the university of liege. Microfluidics is a comparatively new branch of science and technology in which considerable progress has been made in the past 1015 years. Gale fundamentals of micromachining microfluidic system concept concept one system to provide all of the possible required analyses for a given type problem all processing steps are performed on the chip no user interaction required except for initialization portable bedside systems possible labonachip.
Pdf ebook introduction to microfluidics by patrick tabeling pdf format introduction to microfluidics by patrick tabeling click here to access this book. Abate ar1, hung t, sperling ra, mary p, rotem a, agresti jj, weiner ma, weitz da. This book will deal with the basic physical principles involved in microfluidics. The present and future role of microfluidics in biomedical. Introduction to microfluidic techniques weigl 2007. Microfluidics characteristics low reynoldss number, r e laminar flow difficult to mixing large surface to volume ratio surface effect dominant biosurface modification microchannel pressure drop small fluid volume. In the first chapter, it presents a short historical background.
First, we discuss how various types of materials confer new properties and capabilities in the production. It is a young discipline, which is expected to substantially expand over the next few years, stimulated by the considerable development of applications in the pharmaceutical, biomedical and chemical engineering domains. Digital microfluidics open chips microfluidic probes mfp microarrays external pressure capillary effect electrokinetic mechanisms electrowettingon. Fabrication of artificial biomimetic materials has attracted abundant attention. Introduction to microfluidics patrick tabeling translated from french by suelin chen oxford u.
Programmable microfluidics bill thies computer science and artificial intelligence laboratory massachusetts institute of technology uc berkeley october 25, 2007. Universityofljubljana facultyofmathematicsandphysics. Pdmsbased microfluidic technology that was developed in our lab. It offers a crossdisciplinary view of the field, embracing biological, chemical, physical and engineering perspectives. The book is an introduction page 6 if i could only train an ant to do this. Download fundamentals and applications of microfluidics by. Advances in the use of microfluidics to study crystallization. Microfluidics fabrication fabrication batch fabrication microchip cost s2, but limited by package cost parallelization to arrays easy portability increased less. Microfluidics has matured as a technology to the extent that most aspects of microfluidic fabrication and the physics of microflow dynamics have become textbook knowledge over the last decades. This introduction to the emerging field of microfluidics explains how to take advantage of the performance benefits of microfluidics and serves as a. Microfluidics, a technology characterized by the engineered manipulation of fluids at the submillimetre scale, has shown considerable promise for improving. Universityofljubljana facultyofmathematicsandphysics departmentofphysics seminar microfluidics author.
257 940 716 245 820 534 398 633 680 672 195 1275 557 1487 82 861 65 140 858 1299 565 139 678 1343 1473 891 902 143 160 1383 1039 1028 438 981 765 1362 1345 1282 962